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Gram-negative eradication

Gram-negative eradication

The eradication and prevention of Gram-negative rods (GNRs) in the healthcare environment is becoming an increasing and more pressing priority for hospital managers and infection control teams. The control of Gram-negatives is complex due to the fact that most are catalase-positive. Catalase is an enzyme which can break down hydrogen peroxide. Bioquell hydrogen peroxide vapour (HPV) technology is the only HPV technology which is proven to be able to overcome catalase-positive microorganisms

Whether you are concerned about the efficacy or the time taken for your disinfection process, Bioquell is able to offer a tailor-made programme that can eliminate GNR's from single rooms in less than two hours (depending on room size/conditions).

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Our Solutions

  • Whether a hospital is experiencing an outbreak, or endemic GNR issues, Bioquell's Gram-negative Eradication Programme will maximise the benefits from Bioquell's technology, whilst minimising the operational challenges to the hospital
     
  • Bioquell provides a rapid and effective solution that can limit the spread of Gram-negative pathogens
     
  • Working closely with the hospitals infection control team, Bioquell integrate solutions with existing remediation protocols
     
  • In outbreak situations, Bioquell have various service options covering Gram-negative eradication for rooms/units, providing a rapid and cost effective response
     
  • For ongoing Gram-negative prevention, ongoing solutions are available, which can be deployed in response to high incidence or endemic GNR issues
     
  • Bioquell QuAD (Quality Assurance Data) system includes real life data capture and analysis for continuous improvement and deployment optimisation
     

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Benefits

Bioquell's HPV technology offers a number of benefits over other decontamination methods:

  • Successfully eradicate multi-drug resistant catalase-positive Gram-negative rods and other HCAI's with Bioquell HPV. Bioquell is the only technology which is able to overcome catalase-positive GNRs from the environment
     
  • Avoid poor clinical outcomes, increased length of stay and higher patient treatment costs
     
  • Bioquelling a room is more rapid than stringent cleaning protocols and is significantly more effective than terminal cleaning
     
  • Reduced 'cleaning' downtime
     
  • Prevention of bed blocking
     
  • Generation of significant cost benefits
     
  • Full reporting assists hospital management and supports regulatory requirements
     
  • Benefit from Bioquells extensive and worldwide experience of tackling Gram-negative challenges 
     

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FAQs

 
What evidence is there that Bioquell can suppress the spread of Gram-negatives?

Bioquell has been used to control several outbreaks of Gram-negatives around the world. Many of these remain unpublished but several have been published, for example, an outbreak of Acinetobacter and Enterobacter on an ICU in the Netherlands (Otter JA, Yezli S, Schouten MA, van Zanten AR, Houmes-Zielman G, Nohlmans-Paulssen MK. Hydrogen peroxide vapor decontamination of an intensive care unit to remove environmental reservoirs of multidrug-resistant gram-negative rods during an outbreak. Am J Infect Control 2010; 38: 754-756); an outbreak of Serratia marcescens on a neonatal ICU in Sheffield (Bates CJ, Pearse R. Use of hydrogen peroxide vapour for environmental control during a Serratia outbreak in a neonatal intensive care unit. J Hosp Infect 2005; 61: 364-366.); and an outbreak of A. baumannii in an ICU in the USA (Donnegan N, Croxton M, Jones M, Farrare-Wilmore P, Geiser K, Pic-Aluas L. Vaporized Hydrogen Peroxide as Part of a Control Intervention during an Outbreak of Acinetobacter in an ICU. Society for Healthcare Epidemiologists of America Annual Meeting, 2010, Abstract 207). The control of multidrug-resistant Gram-negatives is crucially important in light of the emergence and spread of carbapenemases such as NDM-1 and KPC-2.
 

Can't the same result be achieved by enhanced cleaning?

There is a substantial evidence base supporting the efficacy of enhanced cleaning. This kind of cleaning is usually undertaken with a higher concentration of bleach (sodium hypochlorite). However, bleach has been reported to damage sensitive medical equipment and, due to its strong smell, is poorly tolerated by healthcare workers, patients and visitors.

It's effectiveness, in terms of reliable and repeatable pathogen eradication, is difficult to validate as it relies on the skill and diligence of individual cleaners.

However, bleach cleaning is reletively cheap, is efficacious against micro-organisms if used correctly, and when complemented with Bioquell's HPV, is clearly an important part of the strategy for eradicating Gram-negatives from the inanimate hospital environment. 

 
Are there other technologies out there which do the same?

Not all bio-decontamination technologies are the same. Hospitals are faced with a wide variety of options due to the differences in efficiacy, ability to integrate within hospitals, service options, health and safety and cost.

Bioquell's technology is the only one to have been shown scientifically to reduce healthcare associated infection rates in both an outbreak and endemic setting. 

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Emergency outbreak response

Control a ‘superbug’/ Gram-negative/ C.diff/ norovirus outbreak or bio-clean rooms after a contamination accident. Our emergency response teams will professionally bio-decontaminate your areas, returning them to working capacity.

Call +44 (0)1264 835 835 today.

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Highlights

Emergency outbreak response

Control a ‘superbug’/ Gram-negative/ C.diff/ norovirus outbreak or bio-clean rooms after a contamination accident. Our emergency response teams will professionally bio-decontaminate your areas, returning them to working capacity.

Call +44 (0)1264 835 835 today.

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